About 10 results found for searched term "Melatonin Receptor" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2226 | Melatonin | Melatonin Receptor |
| Melatonex; N-Acetyl-5-methoxytryptamine; MT | ||
| Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. | ||
| M2230 | Agomelatine | Melatonin Receptor |
| Valdoxan; Melitor; S-20098 | ||
| Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity. Agomelatine is also a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. | ||
| M5919 | Ramelteon (TAK-375) | Melatonin Receptor |
| TAK-375 | ||
| Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively. | ||
| M8769 | Tasimelteon | Melatonin Receptor |
| BMS-214778; VEC-162 | ||
| Tasimelteon (BMS-214778) is a Dual Melatonin Receptor Agonist (DMRA) recently approved (Hetlioz) for the treatment of Non-24-hour sleep–wake disorder, a disorder primarily found in the totally blind, where a lack of normal synchronization between the 24-hour light–dark cycle and the endogenous circadian rhythm causes it to drift out of alignment with conventional sleep–wake schedules. | ||
| M14011 | 2-Iodomelatonin | Others |
| 2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. | ||
| M14392 | N-Acetyl-5-hydroxytryptamine | Metabolite/Endogenous Metabolite |
| N-Acetylserotonin; Normelatonin; O-Demethylmelatonin | ||
| N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor. | ||
| M29376 | ACH-000143 | Melatonin Receptor |
| ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively. | ||
| M30957 | Piromelatine | Melatonin Receptor |
| Neu-P11 | ||
| Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities. | ||
| M39186 | 5-Methoxytryptamine hydrochloride | 5-HT Receptor |
| 5-Methoxytryptamine hydrochloride, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine hydrochloride has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine hydrochloride is also a potent antioxidant and has radioprotective action. | ||
| M39187 | 5-Methoxytryptamine | 5-HT Receptor |
| 5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action. | ||
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